Background/Objectives: The aim of this study is to investigate the effect on choroidal parameters of drug withdrawal in patients taking α1 adrenergic receptor antagonist (ARA) inhibitors. Methods: In total, 32 eyes of 32 patients under alpha-lytic therapy, and 32 eyes of 32 control subjects, both scheduled for cataract surgery in the fellow eye, were included. EDI-OCT was performed in all patients and subfoveal choroidal thickness (SFCT), luminal choroidal area (LCA), stromal choroidal area (SCA), total choroidal area (TCA), and choroidal vascularity index (CVI) during the preoperative visit were compared with data approximately 1 month after alpha-lytic withdrawal. The same assessments were performed in the control group. Results: SFCT and LCA were significantly reduced in the patients 1 month after alfa-lytic therapy withdrawal (p < 0.05), whereas in the control group, no changes in choroidal parameters were observed. Conclusions: The data proved that α1ARA inhibitors affected choroidal vessels, whereas no modification of choroidal stroma was observed.